CES, by reducing depression and other signs of psychologically engendered chronic stress, may well play a significant role in reducing or eliminating psychogenic inflammation. That being the case, then another mechanism for the effectiveness of CES in reducing pain throughout the body, and engendering an overall return toward a state of wellness can be inferred. By reducing stress CES can rationally be implicated in assuaging or ameliorating all of the inflammation related medical conditions mentioned above, from diabetes to heart disease, stroke, and all of the various “itis” conditions, including pain.